Can a AMD Radeon R9 290 run Oxygen Not Included?

Yes — comfortably

The AMD Radeon R9 290 handles Oxygen Not Included comfortably — roughly 178 FPS at 1080p and 178 FPS at 1440p on high settings.

178FPS @ 1080p
178FPS @ 1440p
167FPS @ 4K

High preset, upscaling off, paired with a AMD Ryzen 7 9800X3D-class processor.

How the AMD Radeon R9 290 measures up

RequirementAMD Radeon R9 290MinimumRecommendedResult
GPU performance score 14 2 2 Recommended
Video memory 4 GB 0 GB 2 GB Recommended
Ray tracing — Not supported Game has no RT N/A
Upscaling FSR Not supported N/A

Recommended settings

For 60 FPS at 1080p

Use the ultra preset. You already clear 60 FPS on high, so this leaves headroom for dips in busy scenes.

At 1440p

Comfortable — around 178 FPS on high.

At 4K

Around 167 FPS on high — genuinely viable.

How other cards handle Oxygen Not Included

Graphics cardTier1080p FPSvs AMD Radeon R9 290
NVIDIA GeForce GTX 780 Ti D 178 ▲ 0 FPS Compare
NVIDIA GeForce GTX 1660 Ti Laptop D 178 ▲ 0 FPS Compare
AMD Radeon R9 290X D 178 ▲ 0 FPS Compare
AMD Radeon RX 570 4GB D 178 ▼ 0 FPS Compare
NVIDIA GeForce RTX 3050 6GB D 178 ▼ 0 FPS Compare
NVIDIA GeForce GTX 1060 3GB D 178 ▼ 0 FPS Compare

Frequently asked questions

Can the AMD Radeon R9 290 run Oxygen Not Included?

The AMD Radeon R9 290 handles Oxygen Not Included comfortably — roughly 178 FPS at 1080p and 178 FPS at 1440p on high settings.

What FPS will I get?

On high settings with upscaling off: roughly 178 FPS at 1080p, 178 FPS at 1440p and 167 FPS at 4K. These are modelled estimates — see our methodology.

What settings should I use?

Start at the ultra preset at 1080p.

Will my processor hold this back?

These figures assume a processor fast enough not to limit the card. If yours is older, run the bottleneck calculator — this title leans on the GPU, so a modest CPU deficit costs less.